Article
The HLA-DRB1*15 phenotype is associated with multiple red blood cell and HLA antibody responsiveness.
Transfusion - 1 Jul 2016
Verduin Esther P, Brand Anneke, van de Watering Leo M G, Roelen Dave L, Kanhai Humphrey H H, Doxiadis Ilias I N, Claas Frans H J, Schonewille Henk
Abstract excerpt
BACKGROUND: Once a patient has produced a red blood cell (RBC) antibody, there is an increased risk of additional antibody formation after subsequent RBC exposure. Recently, we observed that HLA-DRB1*15 was overrepresented in 379 multiple RBC antibody responders compared to controls or 562 patients with a single RBC antibody (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.3-2.3). In this study we evaluated...
Topics
- Antibodies
- Erythrocytes
- Female
- HLA Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Phenotype
- Pregnancy
- Retrospective Studies