Article
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.
Oncogene - 1 Apr 1990
Yuasa Y, Kamiyama T, Kato M, Iwama T, Ikeuchi T, Tonomura A
Abstract excerpt
We tried to detect oncogenes associated with familial adenomatous polyposis by a tumorigenicity assay in nude mice. One polyp and two peripheral blood lymphocyte DNAs out of 12 samples from patients induced Alu-positive tumors. Lymphocyte DNAs from one of 5 healthy people also showed tumorigenic...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA
- DNA, Neoplasm
- Humans
- Hybrid Cells
- Mice
- Mice, Nude
- Molecular Sequence Data
- Multiple Endocrine Neoplasia
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Oncogenes
- Reference Values