Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.

doi:10.1007/BF01729834

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Article

Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.

Annals of hematology - 1 Jun 1991

Inokuchi K, Amuro N, Futaki M, Dan K, Shinohara T, Kuriya S, Okazaki T, Nomura T

Abstract excerpt

The presence of activated transforming genes was investigated in four patients with therapy-related leukemia and in three with therapy-related myelodysplastic syndrome. DNA of bone marrow cells from six of the patients exhibited transforming activity in the tumorigenicity assay. Five of the six p...

Topics

Aged
Chromosome Aberrations
Female
Genes, ras
Humans
Leukemia
Male
Middle Aged
Mutation
Myelodysplastic Syndromes
Oncogenes
Tumor Stem Cell Assay

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