Article
Genetic diversity in german and European populations: looking for substructures and genetic patterns.
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) - 1 Aug 2005
Lamina C, Steffens M, Mueller J, Lohmussaar E, Meitinger T, Wichmann H E
Abstract excerpt
A classical case-control study is a powerful and cost-efficient approach to detect association of genetic markers with complex disease phenotypes. However, only a small fraction of significant association results has been replicated by other studies. Undetected genetic substructures in the population may be one of the reasons for spurious or biased results. The German "Genomic Control" study aims at detecting...
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