Article
Deletion of the UT receptor gene results in the selective loss of urotensin-II contractile activity in aortae isolated from UT receptor knockout mice.
British journal of pharmacology - 1 May 2003
Behm David J, Harrison Stephen M, Ao Zhaohui, Maniscalco Kristeen, Pickering Susan J, Grau Evelyn V, Woods Tina N, Coatney Robert W, Doe Christopher P A, Willette Robert N, Johns Douglas G, Douglas Stephen A
Abstract excerpt
1 Urotensin-II (U-II) is among the most potent mammalian vasoconstrictors identified and may play a role in the aetiology of essential hypertension. Currently, only one mouse U-II receptor (UT) gene has been cloned. It is postulated that this protein is solely responsible for mediating U-II-induced vasoconstriction. 2 This hypothesis has been investigated in the present study, which assessed basal haemodynamics...
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