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Article

ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States).

Cancer causes & control : CCC - 1 Aug 2005

Jones J Shawn, Gu Xiangjun, Lynch Patrick M, Rodriguez-Bigas Miguel, Amos Christopher I, Frazier Marsha L

Abstract excerpt

OBJECTIVE: We examined a G-to-A single nucleotide polymorphism of the ATM gene, to determine if it influences hereditary non-polyposis colorectal cancer (HNPCC) age of onset. HNPCC is caused by mutations in mismatch repair genes, especially hMLH1 and hMSH2. ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16049814
DOI: 10.1007/s10552-005-1540-7

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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