ARCAD: a method for estimating age-dependent disease risk associated with mutation carrier status from family data.

doi:10.1002/gepi.1370120103

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Article

ARCAD: a method for estimating age-dependent disease risk associated with mutation carrier status from family data.

Genetic epidemiology - 1 Jan 1995

Le Bihan C, Moutou C, Brugières L, Feunteun J, Bonaïti-Pellié C

Abstract excerpt

We present ARCAD, a method to estimate the disease risk associated with mutation carrier status using data on families ascertained by affected individuals, in which a germline mutation has been detected. Because the event of interest, the age of onset, is a censored variable, the method uses the survival analysis approach to formulate the likelihood. Provided that selection criteria are clearly defined, the...

Topics

Adolescent
Adult
Age Factors
Child, Preschool
Female
Genes, p53
Genetic Carrier Screening
Genetic Diseases, Inborn
Humans
Infant
Infant, Newborn
Likelihood Functions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Models, Genetic

Mutation

Neoplasms

Pedigree

Source

Open in PubMed

Identifiers

PMID: 7713397
DOI: 10.1002/gepi.1370120103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7713397-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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