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Article

ARCAD: a method for estimating age-dependent disease risk associated with mutation carrier status from family data.

Genetic epidemiology - 1 Jan 1995

Le Bihan C, Moutou C, Brugières L, Feunteun J, Bonaïti-Pellié C

Abstract excerpt

We present ARCAD, a method to estimate the disease risk associated with mutation carrier status using data on families ascertained by affected individuals, in which a germline mutation has been detected. Because the event of interest, the age of onset, is a censored variable, the method uses the survival analysis approach to formulate the likelihood. Provided that selection criteria are clearly defined, the...

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Identifiers

PMID: 7713397
DOI: 10.1002/gepi.1370120103

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