Article
DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.
PloS one - 12 Nov 2010
Berg Marianne, Danielsen Stine A, Ahlquist Terje, Merok Marianne A, Ågesen Trude H, Vatn Morten H, Mala Tom, Sjo Ole H, Bakka Arne, Moberg Ingvild, Fetveit Torunn, Mathisen Øystein, Husby Anders, Sandvik Oddvar, Nesbakken Arild, Thiis-Evensen Espen, Lothe Ragnhild A
Abstract excerpt
The incidence of colorectal cancer (CRC) increases with age and early onset indicates an increased likelihood for genetic predisposition for this disease. The somatic genetics of tumor development in relation to patient age remains mostly unknown. We have examined the mutation status of five known cancer critical genes in relation to age at diagnosis, and compared the genomic complexity of tumors from young...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.