Article
Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions.
Cancer - 1 Nov 2008
Ye Yuanqing, Lippman Scott M, Lee J Jack, Chen Meng, Frazier Marsha L, Spitz Margaret R, Wu Xifeng
Abstract excerpt
BACKGROUND: Cell-cycle checkpoint controls regulate cell-cycle progression and proliferation. Alterations in cell-cycle control mechanisms are linked to tumorigenesis. METHODS: This case-control study included 147 cases and 147 controls. The authors used a pathway-based approach to assess the association between 10 potential functional single-nucleotide polymorphisms from 7 cell-cycle control genes and the risk...
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