Article
Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes.
PloS one - 19 Aug 2009
Kring Sofia I I, Werge Thomas, Holst Claus, Toubro Søren, Astrup Arne, Hansen Torben, Pedersen Oluf, Sørensen Thorkild I A
Abstract excerpt
BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. We investigated the associations of single nucleotide polymorphisms (SNPs) of these genes with obesity and metabolic traits. METHODOLOGY/PRINCIPAL FINDINGS: In a population of 166 200 young men examined...
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