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Article

CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype

10 Mar 2005

Abstract excerpt

A subset of sporadic colon cancers has been shown to have microsatellite instability caused by an epigenetic inactivation of the MLH1 gene by hypermethylation of the the CpG island in its promoter region. We report here that in colorectal cancer, inactivation of the MLH1 gene is frequently accompanied by hypermethylation of the CpG island in the promoter of the mitotic gene checkpoint with forkhead and ring...

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Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15760919
DOI: 10.1093/carcin/bgi058

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