Article
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits.
Genes, brain, and behavior - 1 Nov 2009
Santin L J, Bilbao A, Pedraza C, Matas-Rico E, López-Barroso D, Castilla-Ortega E, Sánchez-López J, Riquelme R, Varela-Nieto I, de la Villa P, Suardíaz M, Chun J, De Fonseca F Rodriguez, Estivill-Torrús G
Abstract excerpt
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA(1) receptor in the regulation of plasticity and neurogenesis in the adult brain. However, no systematic studies have been conducted to investigate whether the LPA(1) receptor is involved in behavior. In this study, we studied the phenotype of maLPA(1)-null mice,...
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