Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERK5 mediates pro-tumorigenic phenotype in non-small lung cancer cells induced by PGE2.

Biochimica et biophysica acta. Molecular cell research - 1 Oct 2024

Filippelli Arianna, Ciccone Valerio, Del Gaudio Cinzia, Simonis Vittoria, Frosini Maria, Tusa Ignazia, Menconi Alessio, Rovida Elisabetta, Donnini Sandra

Abstract excerpt

Lung cancer is the leading cause of cancer-related deaths worldwide, with non-small cell lung cancer (NSCLC) constituting approximately 84 % of all lung cancer cases. The role of inflammation in the initiation and progression of NSCLC tumors has been the focus of extensive research. Among the various inflammatory mediators, prostaglandin E2 (PGE2) plays a pivotal role in promoting the aggressiveness of epithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Cell Line, Tumor

Share to Cell Movement

Share to Cell Proliferation

Share to Dinoprostone

Share to Lung Neoplasms

Source

Identifiers

PMID: 39128596
DOI: 10.1016/j.bbamcr.2024.119810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERK5 mediates pro-tumorigenic phenotype in non-small lung cancer cells induced by PGE2.PMID 39128596Read ↗

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cellsSemantic proximity Read ↗

Expression of EPHA5 in lung adenocarcinoma is associated with lymph node metastasis and EGFR mutation.Semantic proximity Read ↗

Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.Semantic proximity Read ↗

Clinical Significance and Regulation of ERK5 Expression and Function in CancerSemantic proximity Read ↗

eEF2K knockdown synergizes STS to inhibit the angiogenesis of lung adenocarcinoma via TG2/IL-6/VEGFR2 pathwaySemantic proximity Read ↗

Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta.Semantic proximity Read ↗

The Role of Prostaglandin-Endoperoxide Synthase-2 in Chemoresistance of Non-Small Cell Lung CancerSemantic proximity Read ↗

Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cellsSemantic proximity Read ↗

Prostaglandin E2 activates Src signaling in lung adenocarcinoma cell via EP3.Semantic proximity Read ↗

Cigarette smoke-induced endothelial senescence-like phenotype promotes lung adenocarcinoma metastasis via the BMP4-Smad1/5/9-ID1 axis.Semantic proximity Read ↗

EPHA5 mutation impairs natural killer cell-mediated cytotoxicity against non-small lung cancer cells and promotes cancer cell migration and invasion.Semantic proximity Read ↗

CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.