Article
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein.
Nature - 15 Feb 1990
Yost C S, Lopez C D, Prusiner S B, Myers R M, Lingappa V R
Abstract excerpt
A universal feature of integral transmembrane proteins is a hydrophobic peptide segment that spans the lipid bilayer. These hydrophobic domains are important for terminating the translocation of the polypeptide chain across the membrane of the endoplasmic reticulum (a process termed stop transfer) and for integrating the protein into the bilayer. But a role for extracytoplasmic sequences in stop transfer and...
Topics
- Amino Acid Sequence
- Animals
- Chimera
- Chromosome Deletion
- Cricetinae
- Cricetulus
- Cytoplasm
- Female
- Gene Expression
- Molecular Sequence Data
- Mutation
- Oocytes