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Article

Novel roles of hakai in cell proliferation and oncogenesis.

Molecular biology of the cell - 1 Aug 2009

Figueroa Angélica, Kotani Hirokazu, Toda Yoshinobu, Mazan-Mamczarz Krystyna, Mueller Eva-Christina, Otto Albrecht, Disch Lena, Norman Mark, Ramdasi Rasika Mohan, Keshtgar Mohammed, Gorospe Myriam, Fujita Yasuyuki

Abstract excerpt

During tumor development, cells acquire multiple phenotypic changes upon misregulation of oncoproteins and tumor suppressor proteins. Hakai was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex that regulates cell-cell contacts. Here, we present evidence that Hakai plays a crucial role in various cellular processes and tumorigenesis. Overexpression of Hakai affects not only cell-cell...

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Identifiers

PMID: 19535458
DOI: 10.1091/mbc.e08-08-0845
PMCID: PMC2719571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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