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Article

Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication.

Gastroenterology - 1 Aug 2012

von Hahn Thomas, Schiene-Fischer Cordelia, Van Nguyen Dinh, Pfaender Stephanie, Karavul Behya, Steinmann Eike, Potthoff Andrej, Strassburg Christian, Hamdi Nabila, Abdelaziz Ahmed I, Sarrazin Christoph, Müller Tobias, Berg Thomas, Trépo Eric, Wedemeyer Heiner, Manns Michael P, Pietschmann Thomas, Ciesek Sandra

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-prolyl isomerase A (PPIA) that encodes CypA on HCV infection and replication of human...

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Source

Identifiers

PMID: 22580540
DOI: 10.1053/j.gastro.2012.04.053

Genes

PPIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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