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Article

Cyclophilin A-independent recruitment of NS5A and NS5B into hepatitis C virus replication complexes

27 Jan 2010

Abstract excerpt

The mechanisms by which cyclophilin A (CypA) governs hepatitis C virus (HCV) replication remain unknown. Since CypA binds two essential components of the HCV replication complex (RC)--the polymerase NS5B and the phosphoprotein NS5A--we asked in this study whether CypA regulates their RC association. We found that CypA, via its isomerase pocket, locates in a protease-resistant compartment similar to that where HCV...

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PMID: 20107018
DOI: 10.1099/vir.0.018531-0

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