Article
ER stress controls iron metabolism through induction of hepcidin.
Science (New York, N.Y.) - 14 Aug 2009
Vecchi Chiara, Montosi Giuliana, Zhang Kezhong, Lamberti Igor, Duncan Stephen A, Kaufman Randal J, Pietrangelo Antonello
Abstract excerpt
Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Hepcidin overproduction causes anemia of inflammation, whereas its deficiency leads to hemochromatosis. Inflammation and iron are known extracellular stimuli for hepcidin expression. We found that endoplasmic reticulum (ER) stress also induces hepcidin expression and causes hypoferremia and spleen iron sequestration in...
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