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Iron Homeostasis in Health and Disease

20 Jan 2016

Abstract excerpt

Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress, and programmed cell death. The advance in understanding the...

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PMID: 26805813
DOI: 10.3390/ijms17010130

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