[Regulation of body iron homeostasis by hepcidin].

Abstract excerpt

Hepcidin is a circulating antimicrobial peptide mainly synthesized in the liver, which has been recently proposed as a factor regulating the uptake of dietary iron and its release by reticuloendothelial macrophages. Hepcidin is a potent mediator of anemia of inflammation. Disrupted hepcidin expression is thought to mediate the pathological effects of mutations in the HFE gene in hereditary hemochromatosis....

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