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Article

Regulation of Iron Homeostasis and Related Diseases.

Mediators of inflammation - 1 Jan 2020

Li Yikun, Huang Xiali, Wang Jingjing, Huang Ruiling, Wan Dan

Abstract excerpt

The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway and regulates the iron intake from food and erythrocyte recovery into the bloodstream by secreting hepcidin. Under iron deficiency, hypoxia, and hemorrhage, the liver reduces the expression of hepcidin to ensure the erythropoiesis but increases the excretion of hepcidin during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32454791
DOI: 10.1155/2020/6062094
PMCID: PMC7212278

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