Article
Mosaic chromosomal alterations are suppressed in older adults with HIV.
Communications biology - 21 Jul 2026
Behrouzfar Kiarash, Han Win Min, Perera Rashindrie, Li Jason, Scull Katherine E, Howlett Kerryn, Bloch Mark, Baker David A, Eu Beng, Bowden-Reid Ellen, Smith Don E, Hoy Jennifer F, Woolley Ian, Finlayson Robert, Templeton David J, Matthews Gail V, Costello Jane, Dawson Mark A, Dawson Sarah-Jane, Polizzotto Mark N, Petoumenos Kathy, Dharan Nila J, Yeh Paul
Abstract excerpt
Somatic gene mutations (SGMs) that drive clonal haematopoiesis (CH) have been shown to be more prevalent in people with HIV (PWH), potentially contributing to the higher risk of comorbidities in PWH compared to those without HIV. It is unknown whether mosaic chromosomal alterations (mCA), another form of CH, are associated with HIV. We demonstrate, for the first time, a markedly lower prevalence of mosaic...
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