Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2009

Xu Daosong, Sharma Chandan, Hemler Martin E

Abstract excerpt

Using mass spectrometry, we identified ADAM10 (a membrane-associated metalloproteinase) as a partner for TSPAN12, a tetraspanin protein. TSPAN12-ADAM10 interaction was confirmed by reciprocal coimmunoprecipitation in multiple tumor cell lines. TSPAN12, to a greater extent than other tetraspanins (CD81, CD151, CD9, and CD82), associated with ADAM10 but not with ADAM17. Overexpression of TSPAN12 enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Cell Line, Tumor

Share to Gene Knockdown Techniques

Share to Membrane Proteins

Share to Mutation

Share to Tetraspanins

Source

Open in PubMed Open full text

Identifiers

PMID: 19587294
DOI: 10.1096/fj.09-133462
PMCID: PMC2775005

Genes

ADAM10
TSPAN12
APP
ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein.PMID 19587294Read ↗

Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.Semantic proximity Read ↗

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic PotentialSemantic proximity Read ↗

Tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complexSemantic proximity Read ↗

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity Read ↗

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals.Semantic proximity Read ↗

Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Roles in Normal Physiology and DiseaseSemantic proximity Read ↗

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?Semantic proximity Read ↗

Molecular Regulation and Oncogenic Functions of TSPAN8Semantic proximity Read ↗

Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's diseaseSemantic proximity Read ↗

Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality.Semantic proximity Read ↗

Secreted protease ADAMTS18 in development and diseaseSemantic proximity Read ↗

ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.