Article
Linking genetically defined neurons to behavior through a broadly applicable silencing allele.
Neuron - 13 Aug 2009
Kim Jun Chul, Cook Melloni N, Carey Megan R, Shen Chung, Regehr Wade G, Dymecki Susan M
Abstract excerpt
Tools for suppressing synaptic transmission gain power when able to target highly selective neuron subtypes, thereby sharpening attainable links between neuron type, behavior, and disease; and when able to silence most any neuron subtype, thereby offering broad applicability. Here, we present such a tool, RC::PFtox, that harnesses breadth in scope along with high cell-type selection via combinatorial gene...
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