Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila.

doi:10.1002/neu.10029

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Article

Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila.

Journal of neurobiology - 15 Feb 2002

Keller Andreas, Sweeney Sean T, Zars Troy, O'Kane Cahir J, Heisenberg Martin

Abstract excerpt

Targeted inactivation of neurons by expression of toxic gene products is a useful tool to assign behavioral functions to specific neurons or brain structures. Of a variety of toxic gene products tested, tetanus neurotoxin light chain (TNT) has the least severe side effects and can completely block chemical synapses. By using the GAL4 system to drive TNT expression in a subset of chemo- and mechanosensory neurons,...

Topics

Alleles
Animals
Animals, Genetically Modified
Behavior, Animal
Drosophila
Gene Expression
Genetic Vectors
Immunohistochemistry
Locomotion
Metalloendopeptidases
Photic Stimulation
Sensation
Smell
Structure-Activity Relationship
Tetanus Toxin

Source

Open in PubMed

Identifiers

PMID: 11810637
DOI: 10.1002/neu.10029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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