Article
Association of HLA-DR/DQ polymorphism with Alzheimer's disease.
The American journal of the medical sciences - 1 Apr 2015
Mansouri Leila, Messalmani Mariem, Klai Sarra, Bedoui Ines, Derbali Hajer, Gritli Nasreddine, Mrissa Ridha, Fekih-Mrissa Najiba
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a complex disorder, resulting from an interaction between environmental and genetic factors. Several studies have addressed the association of AD with major histocompatibility complex (MHC) polymorphisms without arriving at any definite conclusions. The human leukocyte antigen (HLA) region is the key susceptibility locus in many immunological diseases. The aim of this study...
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