High frequencies of B8, DR3 and C4A null alleles and immunological disorders in a family of four generations.

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Article

High frequencies of B8, DR3 and C4A null alleles and immunological disorders in a family of four generations.

Journal of clinical & laboratory immunology - 1 Apr 1990

Lokki M L, Meri S, Partanen J, Koskimies S

Abstract excerpt

In a Finnish family covering four generations many members had immunological symptoms or disorders (mostly skin or joint oriented) with the presence of the B8 antigen positive Major Histocompatibility Complex (MHC) haplotype. Immunological parameters including the presence of autoantibodies, quantitative analysis of the complement components C4, Factor B (BF) and C3 and the serum capacity to inhibit immune...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune Diseases
Child
Complement C4a
Disease Susceptibility
Female
Finland
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-B8 Antigen

HLA-DR3 Antigen

Haplotypes

Humans

Hypersensitivity

Lactoylglutathione Lyase

Male

Source

Open in PubMed

Identifiers

PMID: 1967060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1967060-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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