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Article

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.

The Journal of clinical investigation - 1 Aug 2011

Kodama Takahiro, Takehara Tetsuo, Hikita Hayato, Shimizu Satoshi, Shigekawa Minoru, Tsunematsu Hinako, Li Wei, Miyagi Takuya, Hosui Atsushi, Tatsumi Tomohide, Ishida Hisashi, Kanto Tatsuya, Hiramatsu Naoki, Kubota Satoshi, Takigawa Masaharu, Tomimaru Yoshito, Tomokuni Akira, Nagano Hiroaki, Doki Yuichiro, Mori Masaki, Hayashi Norio

Abstract excerpt

The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. In addition, accumulation of p53 has been observed in the hepatocytes of individuals with fibrotic liver diseases, but the significance of this is not known. Herein, we have mechanistically linked p53 activation in hepatocytes to liver fibrosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21747166
DOI: 10.1172/JCI44957
PMCID: PMC3148730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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