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Article

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

29 Jan 2018

Abstract excerpt

A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Neurodegeneration may occur via transcription of the repeats into inherently toxic repetitive sense and antisense RNA species, or via repeat-associated non-ATG initiated translation (RANT) of sense and antisense RNA into toxic dipeptide repeat proteins. We...

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PMID: 29380049
DOI: 10.1007/s00401-017-1798-3

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