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Article

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns.

Journal of lipid research - 1 Jul 2017

Kim Daniel Seung, Jackson Anne U, Li Yatong K, Stringham Heather M, Kuusisto Johanna, Kangas Antti J, Soininen Pasi, Ala-Korpela Mika, Burant Charles F, Salomaa Veikko, Boehnke Michael, Laakso Markku, Speliotes Elizabeth K

Abstract excerpt

A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk. To identify mediators of the effects of TM6SF2, we tested for associations between rs58542926-T and serum lipoprotein/metabolite measures in cross-sectional data from nondiabetic statin-naïve...

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Identifiers

PMID: 28539357
DOI: 10.1194/jlr.P076034
PMCID: PMC5496043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns.PMID 28539357Read ↗

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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.Semantic proximity Read ↗

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Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes.Semantic proximity Read ↗

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