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Article

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice.

Haematologica - 1 May 2008

Falini Brunangelo, Martelli Maria Paola, Mecucci Cristina, Liso Arcangelo, Bolli Niccolò, Bigerna Barbara, Pucciarini Alessandra, Pileri Stefano, Meloni Giovanna, Martelli Massimo F, Haferlach Torsten, Schnittger Susanne

Abstract excerpt

We investigated the NPM1 mutation status or subcellular expression of NPM protein (nuclear vs. aberrant cytoplasmic) at diagnosis and relapse in 125 patients with acute myeloid leukemia from Italy and Germany. All 52 patients with acute myeloidleukemia carrying at diagnosis mutated or cytoplasmic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 18367491
DOI: 10.3324/haematol.12225

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18367491-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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