Article
Antigen specificity of gammadelta T cells depends primarily on the flanking sequences of CDR3delta.
The Journal of biological chemistry - 2 Oct 2009
Xi Xueyan, Guo Yang, Chen Hui, Xu Chunping, Zhang Huiyuan, Hu Hongbo, Cui Lianxian, Ba Denian, He Wei
Abstract excerpt
The structural basis that determines the specificity of gammadelta T cell receptor (TCR) recognition remains undefined. Our previous data show that the complementary determining region of human TCRdelta (CDR3delta) is critical to ligand binding. Here we used linear and configurational approaches...
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