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Article

Antigen Recognition Determinants of γδ T Cell Receptors

8 Apr 2005

Abstract excerpt

The molecular basis of gammadelta T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural gammadelta T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRdelta complementarity-determining region 3 (CDR3) motif derived from germ line-encoded...

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PMID: 15821090
DOI: 10.1126/science.1106480

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