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Article

ABCB1 and ABCC1 single-nucleotide polymorphisms in patients treated with clozapine

1 Aug 2017

Abstract excerpt

Abstract: Clozapine (CZ) has superior efficacy to other antipsychotic agents in the treatment of schizophrenia and has been extensively used in clinical practice. ATP-binding cassette (ABC) transporter proteins are responsible for the distribution of various molecules as well as drugs across extracellular and intracellular membranes, including the blood–brain barrier. Genetic variations in these proteins can...

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Cholesterol and Lipid Metabolism
Drug Transport and Resistance Mechanisms
Pharmacological Effects and Toxicity Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28919802
DOI: 10.2147/pgpm.s142314

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