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Article

Effect of Organic Anion Transporting Polypeptide 1B1 on Plasma Concentration Dynamics of Clozapine in Patients with Treatment-Resistant Schizophrenia.

International journal of molecular sciences - 9 Dec 2024

Sato Toshihiro, Kawabata Takeshi, Kumondai Masaki, Hayashi Nagomi, Komatsu Hiroshi, Kikuchi Yuki, Onoguchi Go, Sato Yu, Nanatani Kei, Hiratsuka Masahiro, Maekawa Masamitsu, Yamaguchi Hiroaki, Abe Takaaki, Tomita Hiroaki, Mano Nariyasu

Abstract excerpt

The involvement of drug-metabolizing enzymes and transporters in plasma clozapine (CLZ) dynamics has not been well examined in Japanese patients with treatment-resistant schizophrenia (TRS). Therefore, this clinical study investigated the relationship between single nucleotide polymorphisms (SNPs) of various pharmacokinetic factors (drug-metabolizing enzymes and transporters) and dynamic changes in CLZ....

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Identifiers

PMID: 39684938
DOI: 10.3390/ijms252313228
PMCID: PMC11642635

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