Article
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science (New York, N.Y.) - 18 Sept 2009
Yun Jihye, Rago Carlo, Cheong Ian, Pagliarini Ray, Angenendt Philipp, Rajagopalan Harith, Schmidt Kerstin, Willson James K V, Markowitz Sandy, Zhou Shibin, Diaz Luis A, Velculescu Victor E, Lengauer Christoph, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas
Abstract excerpt
Tumor progression is driven by genetic mutations, but little is known about the environmental conditions that select for these mutations. Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of their KRAS or BRAF genes, we found that GLUT1, encoding glucose transporter-1, was one of three genes consistently up-regulated in cells with KRAS or BRAF...
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