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Article

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.

Molecular & cellular proteomics : MCP - 1 Sept 2016

Hutton Josiah E, Wang Xiaojing, Zimmerman Lisa J, Slebos Robbert J C, Trenary Irina A, Young Jamey D, Li Ming, Liebler Daniel C

Abstract excerpt

Metabolic reprogramming, in which altered utilization of glucose and glutamine supports rapid growth, is a hallmark of most cancers. Mutations in the oncogenes KRAS and BRAF drive metabolic reprogramming through enhanced glucose uptake, but the broader impact of these mutations on pathways of carbon metabolism is unknown. Global shotgun proteomic analysis of isogenic DLD-1 and RKO colon cancer cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27340238
DOI: 10.1074/mcp.M116.058925
PMCID: PMC5013308

Genes

KRAS
BRAF
DLD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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