Article
An approach to predicting hematopoietic stem cell transplantation outcome using HLA-mismatch information mapped on protein structure data.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Sept 2009
Dudkiewicz Małgorzata, Malanowski Piotr, Czerwin Ski Jarosław, Pawłowski Krzysztof
Abstract excerpt
In hematopoietic stem cell transplantation (HSCT), the outcome is predicted using HLA-matching procedures, which are very time-consuming. There exists substantial evidence of the importance of early donor acceptance in HSCT outcome. In cases when the donor cannot be perfectly matched, it often is unclear which mismatch is less harmful and thus has a greater likelihood of acceptance. We modeled and analyzed...
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