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Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

21 Feb 2018

Abstract excerpt

The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor-recipient compatibility. The PIRCHE algorithm determines donor-recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years,...

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PMID: 29464898
DOI: 10.1111/iji.12359

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