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Article

Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.

Journal of virology - 1 Mar 2008

Everett Roger D, Parada Carlos, Gripon Philippe, Sirma Hüseyin, Orr Anne

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) mutants that fail to express the viral immediate-early protein ICP0 have a pronounced defect in viral gene expression and plaque formation in limited-passage human fibroblasts. ICP0 is a RING finger E3 ubiquitin ligase that induces the degradation of several cellular proteins. PML, the organizer of cellular nuclear substructures known as PML nuclear bodies or ND10, is one of...

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Share to Antigens, Nuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

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Source

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Identifiers

PMID: 18160441
DOI: 10.1128/JVI.02308-07
PMCID: PMC2258993

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.PMID 18160441Read ↗

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The Replication Defect of ICP0-Null Mutant Herpes Simplex Virus 1 Can Be Largely Complemented by the Combined Activities of Human Cytomegalovirus Proteins IE1 and pp71Semantic proximity Read ↗

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