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Article

Scavenger receptor class B member 1 (SCARB1) variants modulate hepatitis C virus replication cycle and viral load.

Journal of hepatology - 1 Aug 2017

Westhaus Sandra, Deest Maximilian, Nguyen Anna T X, Stanke Frauke, Heckl Dirk, Costa Rui, Schambach Axel, Manns Michael P, Berg Thomas, Vondran Florian W R, Sarrazin Christoph, Ciesek Sandra, von Hahn Thomas

Abstract excerpt

BACKGROUND & AIMS: There are numerous coding and non-coding variants in the SCARB1 gene that encodes scavenger receptor class B member 1 (SR-BI), a key receptor for both high density lipoproteins and hepatitis C virus (HCV). Many have been linked to clinical phenotypes, yet their impact on the HCV replication cycle is incompletely understood. The aim of this study was to analyze the impact of these variants on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28363797
DOI: 10.1016/j.jhep.2017.03.020

Genes

SCARB1

Provenance

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