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Article

Defective Angiogenesis in Mice Lacking Endoglin

28 May 1999

Abstract excerpt

Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells. Loss-of-function mutations in the human endoglin gene ENG cause hereditary hemorrhagic telangiectasia (HHT1), a disease characterized by vascular malformations. Here it is shown that by gestational day 11.5, mice lacking endoglin die from defective vascular development. However, in contrast to...

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Identifiers

PMID: 10348742
DOI: 10.1126/science.284.5419.1534

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Related research

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Defective Angiogenesis in Mice Lacking EndoglinPMID 10348742Read ↗

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Generation of a floxed allele of the mouse Endoglin gene.Semantic proximity Read ↗

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Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.Semantic proximity Read ↗

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