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Article

A role for pericytes as microenvironmental regulators of human skin tissue regeneration

3 Aug 2009

Abstract excerpt

The cellular and molecular microenvironment of epithelial stem and progenitor cells is poorly characterized despite well-documented roles in homeostatic tissue renewal, wound healing, and cancer progression. Here, we demonstrate that, in organotypic cocultures, dermal pericytes substantially enhanced the intrinsically low tissue-regenerative capacity of human epidermal cells that have committed to differentiate...

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PMID: 19652362
DOI: 10.1172/jci38535

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