Article

In Vitro Expansion of Keratinocytes on Human Dermal Fibroblast-Derived Matrix Retains Their Stem-Like Characteristics

2018-08-07

Abstract excerpt

<h4>Summary</h4> The long-term expansion of keratinocytes under serum- and feeder free conditions generally results in diminished proliferation and an increased commitment to terminal differentiation. Here we present a serum and xenogeneic feeder free culture system that retains the self-renewal capacity of primary human keratinocytes. In vivo , the tissue microenvironment is a major contributor to determining c...

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Literature Corpus work: d7b05ff8-6420-5c0d-9394-223afc406f6b
DOI: 10.1101/381178

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