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QTLViewer: an interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations.

G3 (Bethesda, Md.) - 29 Jul 2022

Vincent Matthew, Gerdes Gyuricza Isabela, Keele Gregory R, Gatti Daniel M, Keller Mark P, Broman Karl W, Churchill Gary A

Abstract excerpt

The Collaborative Cross and the Diversity Outbred mouse populations are related multiparental populations, derived from the same 8 isogenic founder strains. They carry >50 M known genetic variants, which makes them ideal tools for mapping genetic loci that regulate phenotypes, including physiological and molecular traits. Mapping quantitative trait loci requires statistical and computational training, which...

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PMID: 35703938
DOI: 10.1093/g3journal/jkac146
PMCID: PMC9339332

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