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Article

[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Jan 2008

Chen Jin-jun, Ma Shi-wu, Wang Zhan-hui, Sun Jian, Hou Jin-lin

Abstract excerpt

OBJECTIVE: The aim was to build a PCR-RFLP method for detecting rtN236T mutants and to observe their kinetics in chronic hepatitis B (CHB) patients. METHODS: Seven CHB patients who had suboptimal viral response or viral breakthrough under adefovir mono-therapy were studied. Part of the HBV reverse transcriptional gene from serial sera samples was sequenced with PCR products or cloned HBV DNA; mutations at rt236...

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PMID: 18226341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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