Order-restricted scores test for the evaluation of population-based case-control studies when the genetic model is unknown.

Abstract excerpt

The Cochran-Armitage (CA) linear trend test for proportions is often used for genotype-based analysis of candidate gene association. Depending on the underlying genetic mode of inheritance, the use of model-specific scores maximises the power. Commonly, the underlying genetic model, i.e. additive, dominant or recessive mode of inheritance, is a priori unknown. Association studies are commonly analysed using...

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