Article
Using propensity score adjustment method in genetic association studies.
Computational biology and chemistry - 1 Jun 2016
Sengupta Chattopadhyay Amrita, Lin Ying-Chao, Hsieh Ai-Ru, Chang Chien-Ching, Lian Ie-Bin, Fann Cathy S J
Abstract excerpt
BACKGROUND: The statistical tests for single locus disease association are mostly under-powered. If a disease associated causal single nucleotide polymorphism (SNP) operates essentially through a complex mechanism that involves multiple SNPs or possible environmental factors, its effect might be missed if the causal SNP is studied in isolation without accounting for these unknown genetic influences. In this...
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