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Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulation

1 Dec 2002

Abstract excerpt

PURPOSE OF REVIEW: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling the mechanism of autoimmunity in this and possibly other diseases. In this review, we describe...

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PMID: 14752330
DOI: 10.1097/00130832-200212000-00002

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