Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.

Arthritis and rheumatism - 1 Jun 2007

Nandula Seshagiri R, Amarnath Shoba, Molinolo Alfredo, Bandyopadhyay Bidhan C, Hall Bradford, Goldsmith Corinne M, Zheng Changyu, Larsson Jonas, Sreenath Taduru, Chen WanJun, Ambudkar Indu S, Karlsson Stefan, Baum Bruce J, Kulkarni Ashok B

Abstract excerpt

OBJECTIVE: Transforming growth factor beta (TGFbeta) plays a key role in the onset and resolution of autoimmune diseases and chronic inflammation. The aim of this study was to delineate the precise function of TGFbeta signaling in salivary gland inflammation. METHODS: We impaired TGFbeta signaling in mouse salivary glands by conditionally inactivating expression of TGFbeta receptor type I (TGFbetaRI), either by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type I
Share to Disease Susceptibility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptor, Transforming Growth Factor-beta Type I

Share to Receptors, Transforming Growth Factor beta

Share to Salivary Glands

Share to Sex Characteristics

Share to Sjogren's Syndrome

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 17530708
DOI: 10.1002/art.22715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.PMID 17530708Read ↗

The ontogeny of mouse salivary gland macrophages is distinct between gendersSemantic proximity Read ↗

X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms.Semantic proximity Read ↗

Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging miceSemantic proximity Read ↗

Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transferSemantic proximity Read ↗

Identifying Fibrogenic Cells Following Salivary Gland Obstructive InjurySemantic proximity Read ↗

Towards further defining the proteome of mouse salivaSemantic proximity Read ↗

IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren’s syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22Semantic proximity Read ↗

IKKβ overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia.Semantic proximity Read ↗

Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model.Semantic proximity Read ↗

NOD mouse model for Sjögren's syndrome: lack of longitudinal stability.Semantic proximity Read ↗

Studies of an Androgen-Binding Protein Knockout Corroborate a Role for Salivary ABP in Mouse Communication.Semantic proximity Read ↗

Ectopic lymphoid structures in the aged lacrimal glandsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.